概述

  • 产品名称Anti-DGAT2L4抗体
    参阅全部 DGAT2L4 一抗
  • 描述
    兔多克隆抗体to DGAT2L4
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C-terminal sequence amino acids 284-333 (GEPLPMPKIE NPSQEIVAKY HTLYIDALRK LFDQHKTKFG ISETQELEII) of human DGAT2L4 (NP_001002254).

  • 阳性对照
    • Fetal brain lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab83182 is purified by peptide affinity chromatography method.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab83182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay, 1:12500.

靶标

  • 功能Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.
  • 组织特异性Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.
  • 序列相似性Belongs to the diacylglycerol acyltransferase family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acyl CoA wax alcohol acyltransferase 2 antibody
    • Acyl-CoA retinol O-fatty-acyltransferase antibody
    • Acyl-CoA wax alcohol acyltransferase 2 antibody
    • ARAT antibody
    • Awat2 antibody
    • AWAT2_HUMAN antibody
    • DC4 antibody
    • Diacylglycerol O acyltransferase 2 like 4 antibody
    • Diacylglycerol O acyltransferase candidate 4 antibody
    • Diacylglycerol O-acyltransferase 2-like protein 4 antibody
    • Diacylglycerol O-acyltransferase candidate 4 antibody
    • hDC4 antibody
    • hWS antibody
    • Long chain alcohol O fatty acyltransferase 2 antibody
    • Long-chain-alcohol O-fatty-acyltransferase 2 antibody
    • MFAT antibody
    • Multifunctional O acyltransferase antibody
    • Multifunctional O-acyltransferase antibody
    • Retinol O-fatty-acyltransferase antibody
    • Wax synthase 2 antibody
    • Wax synthase antibody
    • WS antibody
    see all

Anti-DGAT2L4 antibody 图像

  • Anti-DGAT2L4 antibody (ab83182) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal brain lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

Anti-DGAT2L4 antibody (ab83182)参考文献

This product has been referenced in:
  • Kaylor JJ  et al. Identification of the 11-cis-specific retinyl-ester synthase in retinal Müller cells as multifunctional O-acyltransferase (MFAT). Proc Natl Acad Sci U S A 111:7302-7 (2014). Read more (PubMed: 24799687) »

See 1 Publication for this product

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