概述

  • 产品名称Anti-DFNB31抗体
    参阅全部 DFNB31 一抗
  • 描述
    兔多克隆抗体to DFNB31
  • 特异性ab106980 will not recognise isoform 2.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 385-413 of Human DFNB31 (NP_056219.3, NP_001077354.2, NP_001166896.1).

  • 阳性对照
    • K562 cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 97 kDa.

靶标

  • 功能Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.
  • 疾病相关Defects in WHRN are the cause of deafness autosomal recessive type 31 (DFNB31) [MIM:607084]. DFNB31 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in WHRN are the cause of Usher syndrome type 2D (USH2D) [MIM:611383]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
  • 序列相似性Contains 3 PDZ (DHR) domains.
  • 细胞定位Cytoplasm. Cell projection > stereocilium. Cell projection > growth cone. Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Co-localizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium.
  • Information by UniProt
  • 数据库链接
  • 形式There are 4 isoforms produced by alternative splicing.
  • 别名
    • 1110035G07Rik antibody
    • Autosomal recessive deafness type 31 protein antibody
    • CASK interacting protein CIP98 antibody
    • CIP 98 antibody
    • CIP98 antibody
    • Deafness autosomal recessive 31 antibody
    • DFNB 31 antibody
    • DKFZp434N014 antibody
    • KIAA1526 antibody
    • RP11 9M16.1 antibody
    • USH 2D antibody
    • USH2D antibody
    • Whirlin antibody
    • WHRN antibody
    • WHRN_HUMAN antibody
    • WI antibody
    see all

Anti-DFNB31 antibody 图像

  • Anti-DFNB31 antibody (ab106980) at 1/100 dilution + K562 cell lysate at 35 µg

    Predicted band size : 97 kDa

Anti-DFNB31 antibody (ab106980)参考文献

ab106980 has not yet been referenced specifically in any publications.

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