概述

  • 产品名称Anti-Desmoglein 2抗体- N-terminal
    参阅全部 Desmoglein 2 一抗
  • 描述
    兔多克隆抗体to Desmoglein 2 - N-terminal
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH, from the N-terminal region of human Desmoglein 2.

  • 阳性对照
    • T47D cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab76668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 122 kDa (predicted molecular weight: 122 kDa).
ELISA 1/1000.

靶标

  • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 组织特异性All of the tissues tested and carcinomas.
  • 疾病相关Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性Contains 4 cadherin domains.
  • 结构域Calcium may be bound by the cadherin-like repeats.
  • 细胞定位Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVC 10 antibody
    • ARVC10 antibody
    • ARVD 10 antibody
    • ARVD10 antibody
    • Cadherin family member 5 antibody
    • CDHF 5 antibody
    • CDHF5 antibody
    • CMD1BB antibody
    • Desmoglein 2 antibody
    • Desmoglein-2 antibody
    • Desmoglein2 antibody
    • DSG 2 antibody
    • DSG2 antibody
    • DSG2_HUMAN antibody
    • HDGC antibody
    • HDGC included antibody
    • Human Desmoglein colon antibody
    • MGC117034 antibody
    • MGC117036 antibody
    • MGC117037 antibody
    see all

Anti-Desmoglein 2 antibody - N-terminal 图像

  • Anti-Desmoglein 2 antibody - N-terminal (ab76668) at 1/50 dilution + T47D cell lysate at 35 µg

    Predicted band size : 122 kDa
    Observed band size : 122 kDa

Anti-Desmoglein 2 antibody - N-terminal (ab76668)参考文献

This product has been referenced in:
  • Resnik N  et al. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 286:1499-507 (2011). WB ; Dog . Read more (PubMed: 21071449) »
  • Lokar M  et al. Protruding membrane nanotubes: attachment of tubular protrusions to adjacent cells by several anchoring junctions. Protoplasma 246:81-7 (2010). ICC/IF ; Human . Read more (PubMed: 20526853) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab76668.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"