Anti-Desmoglein 2抗体[EPR6767(B)] (ab124683)


  • 产品名称Anti-Desmoglein 2抗体[EPR6767(B)]
    参阅全部 Desmoglein 2 一抗
  • 描述
    兔单克隆抗体[EPR6767(B)] to Desmoglein 2
  • 经测试应用适用于: WB, IP, Flow Cytmore details
    不适用于: ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide, corresponding to residues in the extracellular domain of Human Desmoglein 2.

  • 阳性对照
    • SKBR3, HepG2, 293T, A431, HeLa and T47D cell lysates; T47D cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50000 - 1/200000. Detects a band of approximately 160 kDa (predicted molecular weight: 122 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC or IHC-P.
  • 靶标

    • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    • 组织特异性All of the tissues tested and carcinomas.
    • 疾病相关Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
      Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • 序列相似性Contains 4 cadherin domains.
    • 结构域Calcium may be bound by the cadherin-like repeats.
    • 细胞定位Cell membrane. Cell junction > desmosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ARVC 10 antibody
      • ARVC10 antibody
      • ARVD 10 antibody
      • ARVD10 antibody
      • Cadherin family member 5 antibody
      • CDHF 5 antibody
      • CDHF5 antibody
      • CMD1BB antibody
      • Desmoglein 2 antibody
      • Desmoglein-2 antibody
      • Desmoglein2 antibody
      • DSG 2 antibody
      • DSG2 antibody
      • DSG2_HUMAN antibody
      • HDGC antibody
      • HDGC included antibody
      • Human Desmoglein colon antibody
      • MGC117034 antibody
      • MGC117036 antibody
      • MGC117037 antibody
      see all

    Anti-Desmoglein 2 antibody [EPR6767(B)] 图像

    • All lanes : Anti-Desmoglein 2 antibody [EPR6767(B)] (ab124683) at 1/50000 dilution

      Lane 1 : SKBR3 cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : A431 cell lysate
      Lane 5 : HeLa cell lysate
      Lane 6 : T47D cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 122 kDa
    • ab124683 at 1/10 dilution staining Desmoglein 2 in T47D cells by Flow Cytometry (red). Rabbit IgG negative control (green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-Desmoglein 2 antibody [EPR6767(B)] (ab124683)参考文献

    This product has been referenced in:
    • Kamekura R  et al. Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell 26:3165-77 (2015). Read more (PubMed: 26224314) »

    See 1 Publication for this product

    Product Wall

    Application Immunoprecipitation
    Immuno-precipitation step Protein A/G
    Sample Mouse Cell lysate - whole cell (Hl-1 (murine cardiac muscel cell line))
    Specification Hl-1 (murine cardiac muscel cell line)
    Total protein in input 500 µg

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    提交于 Dec 31 2013

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