Anti-Desmoglein 2抗体(ab96761)

概述

  • 产品名称Anti-Desmoglein 2抗体
    参阅全部 Desmoglein 2 一抗
  • 描述
    兔多克隆抗体to Desmoglein 2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 1 and 176 of Desmoglein 2 (NP_001934).

  • 阳性对照
    • WB: 293T, H1299 and MOLT4 whole cell lysates; HepG2 cell lysate IHC-P: DU145 xenograft

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab96761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 122 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 组织特异性All of the tissues tested and carcinomas.
  • 疾病相关Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性Contains 4 cadherin domains.
  • 结构域Calcium may be bound by the cadherin-like repeats.
  • 细胞定位Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVC 10 antibody
    • ARVC10 antibody
    • ARVD 10 antibody
    • ARVD10 antibody
    • Cadherin family member 5 antibody
    • CDHF 5 antibody
    • CDHF5 antibody
    • CMD1BB antibody
    • Desmoglein 2 antibody
    • Desmoglein-2 antibody
    • Desmoglein2 antibody
    • DSG 2 antibody
    • DSG2 antibody
    • DSG2_HUMAN antibody
    • HDGC antibody
    • HDGC included antibody
    • Human Desmoglein colon antibody
    • MGC117034 antibody
    • MGC117036 antibody
    • MGC117037 antibody
    see all

Anti-Desmoglein 2 antibody 图像

  • All lanes : Anti-Desmoglein 2 antibody (ab96761) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : MOLT4 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 122 kDa
  • Immunohistochemical analysis of Desmoglein 2 in paraffin embedded DU145 xenograft, using ab96761 at a 1/100 dilution.

Anti-Desmoglein 2 antibody (ab96761)参考文献

ab96761 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihre Geduld. Ich kann Ihnen jetzt auch bestätigen, dass der ab14415 ein Epitop auf dem extrazellulären Part des Desmoglein 2 erkennt. Auch der ab96761 erkennt das extrazelluläre Desmoglein 2, da der Antikörper gegen ein rekombina...

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