Anti-Desmoglein 1抗体[3G131] (ab14414)

概述

  • 产品名称Anti-Desmoglein 1抗体[3G131]
    参阅全部 Desmoglein 1 一抗
  • 描述
    小鼠单克隆抗体[3G131] to Desmoglein 1
  • 特异性This antibody does not cross-react with Desmoglein 2 or Desmoglein 3.
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Intracellular domain of Desmoglein 1 (Human).

  • 阳性对照
    • Differentiated keratinocytes and Desmoglein 1 transfected cells.
  • 常规说明For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

性能

应用

Our Abpromise guarantee covers the use of ab14414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 114 kDa.
IP Use a concentration of 5 - 10 µg/ml.

靶标

  • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 组织特异性Epidermis, tongue, tonsil and esophagus.
  • 疾病相关Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
  • 序列相似性Contains 4 cadherin domains.
  • 结构域Calcium may be bound by the cadherin-like repeats.
  • 细胞定位Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cadherin family member 4 antibody
    • CDHF4 antibody
    • Desmoglein-1 antibody
    • Desmosomal glycoprotein 1 antibody
    • DG1 antibody
    • DGI antibody
    • DSG antibody
    • DSG1 antibody
    • DSG1_HUMAN antibody
    • EPKHE antibody
    • EPKHIA antibody
    • Pemphigus foliaceus antigen antibody
    • PPKS1 antibody
    • SPPK1 antibody
    see all

Anti-Desmoglein 1 antibody [3G131] (ab14414)参考文献

ab14414 has not yet been referenced specifically in any publications.

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