Anti-Desmocollin 2抗体(ab76628)

概述

  • 产品名称Anti-Desmocollin 2抗体
    参阅全部 Desmocollin 2 一抗
  • 描述
    小鼠单克隆抗体to Desmocollin 2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human, Chimpanzee, Rhesus monkey
  • 免疫原

    Recombinant fragment: SREASPRSAM STATVTVNVE DQDEGPECNP PIQTVRMKEN AEVGTTSNGY KAYDPETRSS SGIRYKKLTD PTGWVTIDEN TGSIKVFRSL D, corresponding to amino acids 444-535 of Human Desmocollin 2 (NP_077740) with tag.

  • 阳性对照
    • Recombinant tagged human Desmocollin 2 fragment.

性能

应用

Our Abpromise guarantee covers the use of ab76628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 100 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
    • 组织特异性Expressed in epithelia, myocardium and lymph nodes.
    • 疾病相关Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    • 序列相似性Contains 5 cadherin domains.
    • 结构域Calcium may be bound by the cadherin-like repeats.
    • 细胞定位Cell membrane. Cell junction > desmosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ARVD11 antibody
      • Cadherin family member 2 antibody
      • CDHF2 antibody
      • Desmocollin 3 antibody
      • Desmocollin-2 antibody
      • Desmocollin-3 antibody
      • Desmocollin2 antibody
      • Desmosomal glycoprotein II and III antibody
      • Desmosomal glycoprotein II antibody
      • Desmosomal glycoprotein II/III antibody
      • Desmosomal glycoprotein III antibody
      • DG2 antibody
      • DGII/III antibody
      • DKFZp686I11137 antibody
      • DSC 2 antibody
      • DSC2 antibody
      • DSC2_HUMAN antibody
      • DSC3 antibody
      see all

    Anti-Desmocollin 2 antibody 图像

    • Anti-Desmocollin 2 antibody (ab76628) at 1 µg/ml + Recombinant tagged human Desmocollin 2 fragment at 0.2 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 100 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    Anti-Desmocollin 2 antibody (ab76628)参考文献

    ab76628 has not yet been referenced specifically in any publications.

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