概述

  • 产品名称Anti-Desmocollin 2抗体
    参阅全部 Desmocollin 2 一抗
  • 描述
    小鼠多克隆抗体to Desmocollin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human Desmocollin 2 protein (Isoform 2B; NP_004940.1).

  • 阳性对照
    • Desmocollin 2 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab72792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 93 kDa.

靶标

  • 功能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • 组织特异性Expressed in epithelia, myocardium and lymph nodes.
  • 疾病相关Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性Contains 5 cadherin domains.
  • 结构域Calcium may be bound by the cadherin-like repeats.
  • 细胞定位Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVD11 antibody
    • Cadherin family member 2 antibody
    • CDHF2 antibody
    • Desmocollin 3 antibody
    • Desmocollin-2 antibody
    • Desmocollin-3 antibody
    • Desmocollin2 antibody
    • Desmosomal glycoprotein II and III antibody
    • Desmosomal glycoprotein II antibody
    • Desmosomal glycoprotein II/III antibody
    • Desmosomal glycoprotein III antibody
    • DG2 antibody
    • DGII/III antibody
    • DKFZp686I11137 antibody
    • DSC 2 antibody
    • DSC2 antibody
    • DSC2_HUMAN antibody
    • DSC3 antibody
    see all

Anti-Desmocollin 2 antibody 图像

  • All lanes : Anti-Desmocollin 2 antibody (ab72792) at 1/500 dilution

    Lane 1 : Desmocollin 2 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 93 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)

Anti-Desmocollin 2 antibody (ab72792)参考文献

This product has been referenced in:
  • Lowndes M  et al. Different roles of cadherins in the assembly and structural integrity of the desmosome complex. J Cell Sci 127:2339-50 (2014). Read more (PubMed: 24610950) »

See 1 Publication for this product

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