Anti-Desmin抗体(ab80503)
Key features and details
- Goat polyclonal to Desmin
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-Desmin抗体
参阅全部 Desmin 一抗 -
描述
山羊多克隆抗体to Desmin -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse
预测可用于: Cow, Dog -
免疫原
Synthetic peptide:
C-RDGEVVSEATQQQHE
, corresponding to C terminal amino acids 454 - 468 of Human Desmin (NP_001918.3) -
阳性对照
- WB: Mouse skeletal muscle.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
-
纯度
Ammonium Sulphate Precipitation -
纯化说明
ab80503 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab80503于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 54 kDa.
1 hour primary incubation is recommended for this product. |
说明 |
---|
WB
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 54 kDa. 1 hour primary incubation is recommended for this product. |
靶标
-
功能
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. -
疾病相关
Defects in DES are the cause of myopathy myofibrillar desmin-related (MFM-DES) [MIM:601419]; also known as desmin-related myopathy (DRM). A neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.
Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400]. Kaeser syndrome is an autosomal dominant disorder with a peculiar scapuloperoneal distribution of weakness and atrophy. A large clinical variability is observed ranging from scapuloperoneal, limb grindle and distal phenotypes with variable cardiac or respiratory involvement. Facial weakness, dysphagia and gynaecomastia are frequent additional symptoms. Affected men seemingly bear a higher risk of sudden, cardiac death as compared to affected women. Histological and immunohistochemical examination of muscle biopsy specimens reveal a wide spectrum of findings ranging from near normal or unspecific pathology to typical, myofibrillar changes with accumulation of desmin. -
序列相似性
Belongs to the intermediate filament family. -
细胞定位
Cytoplasm. - Information by UniProt
-
数据库链接
- Entrez Gene: 280765 Cow
- Entrez Gene: 497091 Dog
- Entrez Gene: 13346 Mouse
- SwissProt: O62654 Cow
- SwissProt: Q5XFN2 Dog
- SwissProt: P31001 Mouse
- Unigene: 6712 Mouse
-
别名
- CMD1I antibody
- CSM1 antibody
- CSM2 antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (5)
ab80503 被引用在 5 文献中.
- Han B et al. Fat-associated lymphoid clusters as expandable niches for ectopic liver development. Hepatology 76:357-371 (2022). PubMed: 34890068
- Song K et al. Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance. Stroke Vasc Neurol 7:222-236 (2022). PubMed: 35101948
- Lamotte JD et al. hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins. Front Pharmacol 11:617867 (2020). PubMed: 33519485
- Shimizu Y et al. Angiotensin II subtype 1a receptor signaling in resident hepatic macrophages induces liver metastasis formation. Cancer Sci 108:1757-1768 (2017). IHC-P ; Mouse . PubMed: 28660748
- Zhao X et al. Spontaneous immortalization of mouse liver sinusoidal endothelial cells. Int J Mol Med 35:617-24 (2015). ICC/IF ; Mouse . PubMed: 25585915