Anti-Dermatopontin抗体(ab112600)

概述

  • 产品名称
    Anti-Dermatopontin抗体
    参阅全部 Dermatopontin 一抗
  • 描述
    兔多克隆抗体to Dermatopontin
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 52-80 of Human Dermatopontin (NP_001928.2).

  • 阳性对照
    • Dermatopontin-transfected 293 cell line lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Ammonium Sulphate Precipitation
  • 纯化说明
    ab112600 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab112600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 24 kDa.

靶标

  • 功能
    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
  • 组织特异性
    Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
  • 序列相似性
    Belongs to the dermatopontin family.
  • 翻译后修饰
    Sulfated on tyrosine residue(s).
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DERM_HUMAN antibody
    • Dermatopontin antibody
    • Dpt antibody
    • TRAMP antibody
    • Tyrosine rich acidic matrix protein antibody
    • Tyrosine-rich acidic matrix protein antibody
    see all

图片

  • All lanes : Anti-Dermatopontin antibody (ab112600) at 1/50 dilution

    Lane 1 : 293 cell line lysates
    Lane 2 : 293 cell line lysates, transiently transfected with the Dermatopontin gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 24 kDa

实验方案

文献

ab112600 has not yet been referenced specifically in any publications.

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