概述

  • 产品名称Anti-DERL3抗体
    参阅全部 DERL3 一抗
  • 描述
    兔多克隆抗体to DERL3
  • 经测试应用适用于: WB, IP, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow
  • 免疫原

    Synthetic peptide:

    QPGGKRLLQTPGFL

    conjugated to KLH, corresponding to amino acids 192-205 of Human DERL3

  • 阳性对照
    • Whole extract of HEK-293T cells expressing recombinant human DERL3 and human HeLa cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 15mM Sodium Azide
    Constituents: 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab69812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
ICC/IF
  • 应用说明ICC/IF: Use at a concentration of 10 - 20 µg/ml.
    IP: Use at a concentration of 5 - 10 µg.
    WB: Use at a concentration of 2 - 5 µg/ml. Predicted molecular weight: 27 kDa.
    Detection of the band by immunoblotting is specifically inhibited by the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
    • 组织特异性Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
    • 序列相似性Belongs to the derlin family.
    • 细胞定位Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C22orf14 antibody
      • Degradation in endoplasmic reticulum protein 3 antibody
      • DER 3 antibody
      • Der1 like domain family member 3 antibody
      • Der1 like protein 3 antibody
      • Der1-like protein 3 antibody
      • DER3 antibody
      • DERL 3 antibody
      • Derl3 antibody
      • DERL3_HUMAN antibody
      • Derlin 3 antibody
      • Derlin 3 protein antibody
      • Derlin-3 antibody
      • Derlin3 antibody
      • DERtrin 3 antibody
      • DERtrin-3 antibody
      • DERtrin3 antibody
      • IZP 6 antibody
      • IZP6 antibody
      • LLN 2 antibody
      • LLN2 antibody
      • MGC71803 antibody
      see all

    Anti-DERL3 antibody (ab69812)参考文献

    ab69812 has not yet been referenced specifically in any publications.

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