概述

  • 产品名称Anti-DERL2抗体
    参阅全部 DERL2 一抗
  • 描述
    兔多克隆抗体to DERL2
  • 特异性This antibody reacts specifically with human 27 kDa DERL2 protein.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from the C-terminal domain of (Human) DERL2 protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab71552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/200 - 1/2000. Predicted molecular weight: 27 kDa.

靶标

  • 功能Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
  • 组织特异性Ubiquitous. Overexpressed in various hepatocarcinomas.
  • 序列相似性Belongs to the derlin family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Carcinoma related antibody
    • CGI 101 antibody
    • Degradation in endoplasmic reticulum protein 2 antibody
    • DER 2 antibody
    • Der1 like domain family member 2 antibody
    • Der1-like protein 2 antibody
    • DER2 antibody
    • DERL 2 antibody
    • DERL2 antibody
    • DERL2_HUMAN antibody
    • Derlin 2 antibody
    • Derlin-2 antibody
    • Derlin2 antibody
    • DERtrin 2 antibody
    • DERtrin-2 antibody
    • DERtrin2 antibody
    • F LAN 1 antibody
    • F LANa antibody
    • F-LAN-1 antibody
    • F-LANa antibody
    • FLANa antibody
    see all

Anti-DERL2 antibody (ab71552)参考文献

ab71552 has not yet been referenced specifically in any publications.

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