概述

  • 产品名称Anti-Deoxyguanosine kinase抗体
    参阅全部 Deoxyguanosine kinase 一抗
  • 描述
    兔多克隆抗体to Deoxyguanosine kinase
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH selected from the C-terminal region of human DGUOK.

  • 阳性对照
    • Mouse thymus tissue lysate, K562 cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明This antibody is purified through a protein G column, eluted with both high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab38013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 32 kDa.

靶标

  • 相关性Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.
  • 数据库链接
  • 别名
    • Deoxyguanosine kinase mitochondrial antibody
    • dGK antibody
    • DGUOK antibody

Anti-Deoxyguanosine kinase antibody 图像

  • All lanes : Anti-Deoxyguanosine kinase antibody (ab38013) at 1/100 dilution

    Lane 1 : Mouse thymus tissue lysate
    Lane 2 : K562 cell lysate


    Predicted band size : 32 kDa
    Observed band size : 32 kDa

Anti-Deoxyguanosine kinase antibody (ab38013)参考文献

This product has been referenced in:
  • Yamauchi T  et al. Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res 34:1657-62 (2014). Human . Read more (PubMed: 24692694) »

See 1 Publication for this product

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