概述

  • 产品名称
    DENN肽

描述

  • 性质
    Synthetic

技术指标

Our Abpromise guarantee covers the use of ab8384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

常规信息

  • 别名
    • Differentially expressed in normal and neoplastic cells
    • FLJ35600
    • IG20
    • Insulinoma glucagonoma clone 20
    • KIAA0358
    • MADD
    • MADD_HUMAN
    • MAP kinase-activating death domain protein
    • Rab3 GDP/GTP exchange factor
    • RAB3GEP
    see all
  • 功能
    Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
  • 组织特异性
    Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
  • 序列相似性
    Belongs to the MADD family.
    Contains 1 dDENN domain.
    Contains 1 death domain.
    Contains 1 DENN domain.
    Contains 1 uDENN domain.
  • 细胞定位
    Membrane.
  • Information by UniProt

文献

ab8384 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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