概述

  • 产品名称
  • 描述
    兔多克隆抗体to DENN
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 1597 and 1647 of Human DENN (NP_003673.3).

  • 阳性对照
    • Human Breast Carcinoma, Colon Carcinoma, Lung Adenocarcinoma, Ovarian Carcinoma and Prostate Carcinoma tissues.

性能

应用

Our Abpromise guarantee covers the use of ab110991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能
    Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
  • 组织特异性
    Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
  • 序列相似性
    Belongs to the MADD family.
    Contains 1 dDENN domain.
    Contains 1 death domain.
    Contains 1 DENN domain.
    Contains 1 uDENN domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Differentially expressed in normal and neoplastic cells antibody
    • FLJ35600 antibody
    • IG20 antibody
    • Insulinoma glucagonoma clone 20 antibody
    • KIAA0358 antibody
    • MADD antibody
    • MADD_HUMAN antibody
    • MAP kinase-activating death domain protein antibody
    • Rab3 GDP/GTP exchange factor antibody
    • RAB3GEP antibody
    see all

图片

  • ab110991 at 1/100 dilution staining DENN in Human colon carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.
    Detection: DAB staining.
  • ab110991 at 1/100 dilution staining DENN in Human colon carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.
    Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1/100.

文献

ab110991 has not yet been referenced specifically in any publications.

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