Anti-Dematin (phospho S403)抗体(ab61044)

概述

  • 产品名称Anti-Dematin (phospho S403)抗体
    参阅全部 Dematin 一抗
  • 描述
    兔多克隆抗体to Dematin (phospho S403)
  • 特异性Detects Dematin only when phosphorylated at serine 403.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from human Dematin around the phosphorylation site of serine 403 (K-A-SP-L-F).

  • 阳性对照
    • Heart tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61044 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 46 kDa.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Actin-bundling protein. May function in mitogen-activated protein kinase pathway.
  • 组织特异性Heart, brain, lung, skeletal muscle, and kidney.
  • 序列相似性Belongs to the villin/gelsolin family.
    Contains 1 HP (headpiece) domain.
  • 结构域Contains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion.
    Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments.
  • 翻译后修饰Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase.
    The N-terminus is blocked.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DEMA antibody
    • DEMA_HUMAN antibody
    • Dematin antibody
    • DMT antibody
    • EPB49 antibody
    • erythrocyte membrane protein band 4.9 (dematin) antibody
    • Erythrocyte membrane protein band 4.9 antibody
    see all

Anti-Dematin (phospho S403) antibody 图像

  • All lanes : Anti-Dematin (phospho S403) antibody (ab61044)

    Lane 1 : HepG2 cells treated with insulin
    Lane 2 : phospho dematin


    Predicted band size : 46 kDa
  • 1/50-1/100 ab61044 staining phosphorilated Dematin on Human heart tissue, in the absence or presence of the immunizing phosphopeptide.

Anti-Dematin (phospho S403) antibody (ab61044)参考文献

ab61044 has not yet been referenced specifically in any publications.

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