概述

  • 产品名称Anti-Deltex抗体
    参阅全部 Deltex 一抗
  • 描述
    兔多克隆抗体to Deltex
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 343-587 of Human Deltex (NP_004407).

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab96439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.

靶标

  • 功能Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
  • 组织特异性Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the Deltex family.
    Contains 1 RING-type zinc finger.
    Contains 2 WWE domains.
  • 结构域The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • 翻译后修饰Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
  • 细胞定位Cytoplasm. Nucleus. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Deltex 1, E3 ubiquitin ligase antibody
    • Deltex homolog 1 (Drosophila) antibody
    • Deltex homolog 1 antibody
    • Deltex protein 1 antibody
    • Deltex-1 antibody
    • Deltex1 antibody
    • dtx1 antibody
    • DTX1_HUMAN antibody
    • E3 ubiquitin protein ligase DTX1 antibody
    • E3 ubiquitin-protein ligase DTX1 antibody
    • FXI-T1 antibody
    • Fxit 1 antibody
    • Fxit1 antibody
    • hDTX1 antibody
    • hDx 1 antibody
    • mDTX1 antibody
    • Protein deltex 1 antibody
    • Protein deltex-1 antibody
    see all

Anti-Deltex antibody 图像

  • Anti-Deltex antibody (ab96439) at 1/1000 dilution + HeLa cell lysate at 30 µg

    Predicted band size : 67 kDa

Anti-Deltex antibody (ab96439)参考文献

ab96439 has not yet been referenced specifically in any publications.

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