概述

  • 产品名称
    Anti-DeltaC抗体[zdc2]
  • 描述
    小鼠单克隆抗体[zdc2] to DeltaC
  • 特异性
    Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.
  • 经测试应用
    适用于: ELISA, WB, IHC-Fr, Flow Cyt, IHC - Wholemount, ICC/IFmore details
  • 种属反应性
    与反应: Zebrafish
  • 免疫原

    Extracellular region of DeltaC protein (Zebrafish).

  • 表位
    DeltaC extracellular domain.
  • 阳性对照
    • HEK293 cells transfected with DeltaC or zebrafish embryo cryosections (formulin fixed).

性能

应用

Our Abpromise guarantee covers the use of ab73336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 73 kDa.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC - Wholemount Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

靶标

  • 相关性
    DeltaC acts as a ligand for Notch receptors and is involved in somitogenesis. It can activate Notch receptors. It is required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
  • 细胞定位
    Membrane; Single-pass type I membrane protein
  • 数据库链接
  • 别名
    • Bea antibody
    • Beamter antibody
    • DelC antibody
    • Dlc antibody

文献

This product has been referenced in:
  • Quillien A  et al. Distinct Notch signaling outputs pattern the developing arterial system. Development 141:1544-52 (2014). Zebrafish . Read more (PubMed: 24598161) »
  • Giudicelli F  et al. Setting the tempo in development: an investigation of the zebrafish somite clock mechanism. PLoS Biol 5:e150 (2007). Read more (PubMed: 17535112) »

See all 2 Publications for this product

客户评价及客户问答

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
IHC - Wholemount
Sample
Zebrafish Tissue sections (whole embryo)
Specification
whole embryo
Username

Ms. Emerald Butko

Verified customer

提交于 Oct 24 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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