概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab66318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 40 kDa).

靶标

  • 相关性Function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. PTM: N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
  • 细胞定位Multi pass membrane protein
  • 数据库链接
  • 别名
    • D-OR-1 antibody
    • Delta type opioid receptor antibody
    • Delta type opioid receptor DOR 1 antibody
    • Delta type opioid receptor DOR1 antibody
    • Delta-type opioid receptor antibody
    • DOR 1 antibody
    • DOR-1 antibody
    • DOR1 antibody
    • mDOR antibody
    • Nbor antibody
    • Opioid receptor delta 1 antibody
    • OPRD 1 antibody
    • OPRD antibody
    • OPRD_HUMAN antibody
    • Oprd1 antibody
    see all

Anti-Delta Opioid Receptor antibody 图像

  • All lanes : Anti-Delta Opioid Receptor antibody (ab66318) at 1/500 dilution

    Lane 1 : human brain lysate at 10 µg
    Lane 2 : rat brain lysate at 10 µg
    Lane 3 : mouse brain lysate at 10 µg


    Predicted band size : 40 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)

Anti-Delta Opioid Receptor antibody (ab66318)参考文献

This product has been referenced in:
  • Quelch DR  et al. Imaging endogenous opioid peptide release with [(11)C]carfentanil and [(3)H]diprenorphine: influence of agonist-induced internalization. J Cereb Blood Flow Metab N/A:N/A (2014). Read more (PubMed: 25005876) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab66318.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"