Anti-delta 1 Catenin (phospho Y228)抗体(ab61026)

概述

  • 产品名称
    Anti-delta 1 Catenin (phospho Y228)抗体
    参阅全部 delta 1 Catenin 一抗
  • 描述
    兔多克隆抗体to delta 1 Catenin (phospho Y228)
  • 特异性
    Detects endogenous levels of delta 1 Catenin only when phosphorylated at tyrosine 228
  • 经测试应用
    适用于: WB, IHC-P, ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide from around the phosphorylation site of tyrosine 228 (DNYPGS) of human delta 1 Catenin

  • 阳性对照
    • HUVEC cells Human brain tissue

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 108 kDa (predicted molecular weight: 108 kDa).
IHC-P 1/50 - 1/100.
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.

靶标

  • 功能
    Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • 组织特异性
    Expressed in vascular endothelium.
  • 序列相似性
    Belongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • 结构域
    A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • 翻译后修饰
    Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • 细胞定位
    Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cadherin associated Src substrate antibody
    • Cadherin-associated Src substrate antibody
    • CAS antibody
    • Catenin (cadherin associated protein) delta 1 antibody
    • Catenin delta 1 antibody
    • Catenin delta antibody
    • Catenin delta-1 antibody
    • CTND1_HUMAN antibody
    • CTNND 1 antibody
    • CTNND antibody
    • CTNND1 antibody
    • KIAA0384 antibody
    • p120 antibody
    • P120 CAS antibody
    • p120 catenin antibody
    • P120 CTN antibody
    • p120(cas) antibody
    • p120(ctn) antibody
    • P120CAS antibody
    • P120CTN antibody
    see all

图片

  • Immunohistochemical analysis of paraffin embedded human brain tissue using ab61026 at 1/50 dilution. Samples were treated -/+ immunising peptide.
  • All lanes : Anti-delta 1 Catenin (phospho Y228) antibody (ab61026) at 1/500 dilution

    Lane 1 : HUVEC extract
    Lane 2 : HUVEC extract with immunising peptide


    Predicted band size : 108 kDa
    Observed band size : 108 kDa
  • Immunofluorescence analysis of HUVECs labelled with ab61026 at 1/500 dilution. Left: untreated sample. Right: sample treated with immunising peptide.

文献

ab61026 has not yet been referenced specifically in any publications.

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