Anti-delta 1 Catenin抗体(ab74124)

概述

  • 产品名称Anti-delta 1 Catenin抗体
    参阅全部 delta 1 Catenin 一抗
  • 描述
    兔多克隆抗体to delta 1 Catenin
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthesized non phosphopeptide derived from human delta 1 Catenin around the phosphorylation site of tyrosine 228 (D-N-YP-G-S).

  • 阳性对照
    • Extracts from HuvEc cells, human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab74124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 108 kDa (predicted molecular weight: 108 kDa).
ELISA 1/5000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • 组织特异性Expressed in vascular endothelium.
  • 序列相似性Belongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • 结构域A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • 翻译后修饰Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • 细胞定位Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cadherin associated Src substrate antibody
    • Cadherin-associated Src substrate antibody
    • CAS antibody
    • Catenin (cadherin associated protein) delta 1 antibody
    • Catenin delta 1 antibody
    • Catenin delta antibody
    • Catenin delta-1 antibody
    • CTND1_HUMAN antibody
    • CTNND 1 antibody
    • CTNND antibody
    • CTNND1 antibody
    • KIAA0384 antibody
    • p120 antibody
    • P120 CAS antibody
    • p120 catenin antibody
    • P120 CTN antibody
    • p120(cas) antibody
    • p120(ctn) antibody
    • P120CAS antibody
    • P120CTN antibody
    see all

Anti-delta 1 Catenin antibody 图像

  • All lanes : Anti-delta 1 Catenin antibody (ab74124) at 1/500 dilution

    Lane 1 : Extracts from HuvEc cells
    Lane 2 : Extracts from HuvEc cells, plus immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 108 kDa
    Observed band size : 108 kDa
  • ab74124, at a 1/50 dilution, staining delta 1 Catenin in paraffin embedded human brain tissue by Immunohistochemistry, in the absence (left image) or presence (right image) of the immunising peptide.

Anti-delta 1 Catenin antibody (ab74124)参考文献

ab74124 has not yet been referenced specifically in any publications.

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