概述

  • 产品名称
  • 描述
    兔多克隆抗体to DEK
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residue 225 and 275 of Human DEK (NP_003463.1).

  • 阳性对照
    • Human Anaplastic Thyroid Carcinoma, Bladder Cell Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Skin Squamous Cell Carcinoma and Stomach Adenocarcinoma.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab85407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Involved in chromatin organization.
    • 组织特异性
      Ubiquitous. Expressed at relatively high levels.
    • 疾病相关
      A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
    • 序列相似性
      Contains 1 SAP domain.
    • 翻译后修饰
      Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
    • 细胞定位
      Nucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
    • Information by UniProt
    • 数据库链接
    • 别名
      • D6S231E antibody
      • Dek antibody
      • DEK gene antibody
      • DEK oncogene antibody
      • DEK oncogene DNA binding antibody
      • DEK_HUMAN antibody
      • Protein DEK antibody
      see all

    Anti-DEK antibody 图像

    • ab85407, at 1/250 dilution, staining DEK in formalin-fixed, paraffin-embedded human stomach carcinoma by Immunohistochemistry using DAB staining.
    • ab85407, at 1/250 dilution, staining DEK in formalin-fixed, paraffin-embedded human prostate carcinoma by Immunohistochemistry using DAB staining.

    Anti-DEK antibody (ab85407)参考文献

    ab85407 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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