Anti-Deformed Epidermal Autoregulatory Factor 1抗体- C-terminal (ab75722)

概述

  • 产品名称Anti-Deformed Epidermal Autoregulatory Factor 1抗体- C-terminal
    参阅全部 Deformed Epidermal Autoregulatory Factor 1 一抗
  • 描述
    兔多克隆抗体to Deformed Epidermal Autoregulatory Factor 1 - C-terminal
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C-terminal region of mouse Deformed Epidermal Autoregulatory Factor 1 .

  • 阳性对照
    • 293 cell lysate transiently transfected with the Deformed Epidermal Autoregulatory Factor 1 gene.

性能

应用

Our Abpromise guarantee covers the use of ab75722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 59 kDa.
ELISA 1/1000.

靶标

  • 功能Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.
  • 组织特异性Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.
  • 序列相似性Contains 1 MYND-type zinc finger.
    Contains 1 SAND domain.
  • 细胞定位Cytoplasm. Nucleus. When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced; Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270% and Secreted. Secreted in some cell types.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Deaf1 antibody
    • DEAF1 transcription factor antibody
    • DEAF1_HUMAN antibody
    • Deformed epidermal autoregulatory factor 1 homolog antibody
    • Nuclear DEA1 related transcriptional regulator antibody
    • Nuclear DEAF-1-related transcriptional regulator antibody
    • NUDR antibody
    • SPN antibody
    • Suppressin antibody
    • Zinc finger MYND domain containing protein 5 antibody
    • Zinc finger MYND domain-containing protein 5 antibody
    • ZMYND5 antibody
    see all

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - C-terminal 图像

  • All lanes : Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - C-terminal (ab75722) at 1/50 dilution

    Lane 1 : Nontransfected 293 cell lysate
    Lane 2 : 293 cell lysate transiently transfected with the Deformed Epidermal Autoregulatory Factor 1 gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 59 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 68 kDa. We are unsure as to the identity of these extra bands.

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - C-terminal (ab75722)参考文献

ab75722 has not yet been referenced specifically in any publications.

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