Anti-Deformed Epidermal Autoregulatory Factor 1抗体(ab56668)




Our Abpromise guarantee covers the use of ab56668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.
    • 组织特异性Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.
    • 序列相似性Contains 1 MYND-type zinc finger.
      Contains 1 SAND domain.
    • 细胞定位Cytoplasm. Nucleus. When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced; Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270% and Secreted. Secreted in some cell types.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deaf1 antibody
      • DEAF1 transcription factor antibody
      • DEAF1_HUMAN antibody
      • Deformed epidermal autoregulatory factor 1 homolog antibody
      • Nuclear DEA1 related transcriptional regulator antibody
      • Nuclear DEAF-1-related transcriptional regulator antibody
      • NUDR antibody
      • SPN antibody
      • Suppressin antibody
      • Zinc finger MYND domain containing protein 5 antibody
      • Zinc finger MYND domain-containing protein 5 antibody
      • ZMYND5 antibody
      see all

    Anti-Deformed Epidermal Autoregulatory Factor 1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56668 Deformed Epidermal Autoregulatory Factor 1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    Anti-Deformed Epidermal Autoregulatory Factor 1 antibody (ab56668)参考文献

    ab56668 has not yet been referenced specifically in any publications.

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