• 产品名称Anti-DEDD2抗体
    参阅全部 DEDD2 一抗
  • 描述
    兔多克隆抗体to DEDD2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.

  • 阳性对照
    • RAW264.7 cell lysate.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域



Our Abpromise guarantee covers the use of ab36858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 36 kDa).


  • 相关性Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
  • 细胞定位Nuclear, accumulated in subnuclear structures resembling nucleoli.
  • 数据库链接
  • 别名
    • Death effector domain containing 2 antibody
    • Death effector domain-containing DNA-binding protein antibody
    • Death effector domain-containing protein antibody
    • Death effector domain-containing testicular protein antibody
    • DED containing protein FLAME 3 antibody
    • DEFT antibody
    • DNA binding death effector domain containing protein 2 antibody
    • DNA-binding death effector domain-containing protein 2 antibody
    • FADD like anti apoptotic molecule 3 antibody
    • FLAME 3 antibody
    see all

Anti-DEDD2 antibody 图像

  • Lane 1 : Anti-DEDD2 antibody (ab36858) at 0.5 µg/ml
    Lane 2 : Anti-DEDD2 antibody (ab36858) at 1 µg/ml
    Lane 3 : Anti-DEDD2 antibody (ab36858) at 2 µg/ml

    Lane 1 : RAW264.7 cell lysate
    Lane 2 : RAW264.7 cell lysate
    Lane 3 : RAW264.7 cell lysate

    Lysates/proteins at 15 µg/ml per lane.

    Anti-rabbit IgG HRP at 1/10000 dilution

    Predicted band size : 36 kDa
    Observed band size : 26 kDa (why is the actual band size different from the predicted?)

Anti-DEDD2 antibody (ab36858)参考文献

ab36858 has not yet been referenced specifically in any publications.

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