Anti-DEDD2抗体(ab36858)

概述

• 产品名称
  Anti-DEDD2抗体
  参阅全部 DEDD2 一抗
• 描述
  兔多克隆抗体to DEDD2
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  A peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.

• 阳性对照
  • RAW264.7 cell lysate.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C.
• 存储溶液
  Preservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • RAW 264.7 whole cell lysate (ab7187)

应用

靶标

• 相关性
  Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
• 细胞定位
  Nuclear, accumulated in subnuclear structures resembling nucleoli.
• 数据库链接
  • Entrez Gene: 162989 Human
  • Entrez Gene: 67379 Mouse
  • Entrez Gene: 687118 Rat
  • Omim: 606841 Human
  • SwissProt: Q8WXF8 Human
  • SwissProt: Q8QZV0 Mouse
  • Unigene: 515432 Human
  • Unigene: 280594 Mouse
• 别名
  • Death effector domain containing 2 antibody
  • Death effector domain-containing DNA-binding protein antibody
  • Death effector domain-containing protein antibody

  • Death effector domain-containing testicular protein antibody
  • DED containing protein FLAME 3 antibody
  • DEFT antibody
  • DNA binding death effector domain containing protein 2 antibody
  • DNA-binding death effector domain-containing protein 2 antibody
  • FADD like anti apoptotic molecule 3 antibody
  • FLAME 3 antibody

  see all

实验方案

• Western blot protocols