概述

  • 产品名称Anti-DEDD2抗体
    参阅全部 DEDD2 一抗
  • 描述
    兔多克隆抗体to DEDD2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 179-228 (PQQQSEPARP SSEGKVTCDI RLRVRAEYCE HGPALEQGVA SRRPQALARQ) of Human DEDD2 (NP_579874)

  • 阳性对照
    • Human fetal lung lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
  • 细胞定位Nuclear, accumulated in subnuclear structures resembling nucleoli.
  • 数据库链接
  • 别名
    • Death effector domain containing 2 antibody
    • Death effector domain-containing DNA-binding protein antibody
    • Death effector domain-containing protein antibody
    • Death effector domain-containing testicular protein antibody
    • DED containing protein FLAME 3 antibody
    • DEFT antibody
    • DNA binding death effector domain containing protein 2 antibody
    • DNA-binding death effector domain-containing protein 2 antibody
    • FADD like anti apoptotic molecule 3 antibody
    • FLAME 3 antibody
    see all

Anti-DEDD2 antibody 图像

  • Anti-DEDD2 antibody (ab104350) at 1 µg/ml + Human fetal lung lysate at 10 µg

    Predicted band size : 36 kDa

Anti-DEDD2 antibody (ab104350)参考文献

ab104350 has not yet been referenced specifically in any publications.

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