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功能
Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
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组织特异性
Present in vascular smooth cells (at protein level).
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序列相似性
Belongs to the helicase family.
Contains 2 CARD domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
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结构域
The repressor domain controls homomultimerization and interaction with MAVS.
The helicase domain is responsible for dsRNA recognition.
The 2 CARD domains are responsible for interaction with and signaling through MAVS.
The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination.
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翻译后修饰
Isgylated. Conjugated to ubiquitin-like protein ISG15 upon IFN-beta stimulation.
Ubiquitinated. Undergoes 'Lys-63'-linked ubiquitination. Lys-172 is the critical site for TRIM25-mediated ubiquitination, for MAVS binding and to induce anti-viral signal transduction. Lys-154, Lys-164 and Lys-172 are critical sites for RNF135-mediated ubiquitination. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains.
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细胞定位
Cytoplasm. Colocalized with TRIM25 at cytoplasmic perinuclear bodies.
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Information by UniProt
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数据库链接
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别名
- Ddx58 antibody
- DDX58_HUMAN antibody
- DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody
- DEAD (Asp Glu Ala Asp/His) box polypeptide antibody
- DEAD box protein 58 antibody
- DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody
- DKFZp434J1111 antibody
- DKFZp686N19181 antibody
- FLJ13599 antibody
- Probable ATP dependent RNA helicase DDX58 antibody
- Probable ATP-dependent RNA helicase DDX58 antibody
- Retinoic acid inducible gene 1 protein antibody
- Retinoic acid-inducible gene 1 protein antibody
- Retinoic acid-inducible gene I protein antibody
- RIG I antibody
- Rig-1 antibody
- RIG-I antibody
- RIG1 antibody
- rigi antibody
- RLR 1 antibody
- RNA helicase antibody
- RNA helicase RIG I antibody
- SGMRT2 antibody
see all