Anti-DDX4 / MVH抗体[EPR3849] (ab108392)


  • 产品名称Anti-DDX4 / MVH抗体[EPR3849]
    参阅全部 DDX4 / MVH 一抗
  • 描述
    兔单克隆抗体[EPR3849] to DDX4 / MVH
  • 经测试应用适用于: WB, IPmore details
    不适用于: Flow Cyt,ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human DDX4/ MVH

  • 阳性对照
    • Human testis, Human ovary cancer, K562, seminoma, HeLa, NCCIT and LNCaP cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab108392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 83 kDa (predicted molecular weight: 79 kDa).
IP 1/10 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
  • 靶标

    • 功能Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle.
    • 组织特异性Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
    • 序列相似性Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
      Contains 1 helicase ATP-binding domain.
      Contains 1 helicase C-terminal domain.
    • 细胞定位Cytoplasm. Cytoplasm, perinuclear region. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DDX 4 antibody
      • Ddx4 antibody
      • DDX4_HUMAN antibody
      • DEAD (Asp Glu Ala Asp) box polypeptide 4 antibody
      • DEAD box protein 4 antibody
      • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 antibody
      • MVH antibody
      • Probable ATP dependent RNA helicase DDX4 antibody
      • Probable ATP-dependent RNA helicase DDX4 antibody
      • VASA antibody
      • Vasa homolog antibody
      see all

    Anti-DDX4 / MVH antibody [EPR3849] 图像

    • All lanes : Anti-DDX4 / MVH antibody [EPR3849] (ab108392) at 1/10000 dilution

      Lane 1 : Human testis lysate
      Lane 2 : Human ovary cancer lysate
      Lane 3 : K562 cell lysate
      Lane 4 : Seminoma cell lysate
      Lane 5 : HeLa cell lysate
      Lane 6 : NCCIT cell lysate
      Lane 7 : LNCaP cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 79 kDa
      Observed band size : 83 kDa (why is the actual band size different from the predicted?)

    Anti-DDX4 / MVH antibody [EPR3849] (ab108392)参考文献

    ab108392 has not yet been referenced specifically in any publications.

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