概述

  • 产品名称Anti-DDX23抗体
    参阅全部 DDX23 一抗
  • 描述
    兔多克隆抗体to DDX23
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Gorilla, Chinese Hamster, Orangutan, Platypus (Ornithorhynchus anatinus), Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 of Human DDX23 (NP_004809.2).

  • 阳性对照
    • Breast Carcinoma, Non-Small Cell Lung Cancer, Stomach Adenocarcinom

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab96254 was affinity purified using an epitope specific to DDX23 immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab96254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended, with tris-EDTA pH 9.0 buffer to enhance staining. Likely to work with frozen sections.

靶标

  • 功能Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.
  • 序列相似性Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 翻译后修饰In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 100 kDa U5 snRNP-specific protein antibody
    • DDX23 antibody
    • DDX23_HUMAN antibody
    • DEAD box protein 23 antibody
    • EC 3.6.1.- antibody
    • Probable ATP-dependent RNA helicase DDX23 antibody
    • PRP28 homolog antibody
    • U5-100kD antibody
    see all

Anti-DDX23 antibody 图像

  • ab96254, at 1/250 dilution, staining DDX23 in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry using DAB detection. Epitope retrieval was performed.

Anti-DDX23 antibody (ab96254)参考文献

ab96254 has not yet been referenced specifically in any publications.

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