概述

  • 产品名称Anti-DDRGK1抗体
    参阅全部 DDRGK1 一抗
  • 描述
    兔多克隆抗体to DDRGK1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 143-192 of Human DDRGK1 (NP_076424).

  • 阳性对照
    • MCF7 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab99121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress.
  • 组织特异性Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
  • 序列相似性Belongs to the DDRGK1 family.
    Contains 1 PCI domain.
  • 翻译后修饰Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.
    Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.
  • 细胞定位Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110001I20Rik antibody
    • 2600009E05Rik antibody
    • C20orf116 antibody
    • Chromosome 20 open reading frame 116 antibody
    • Dashurin antibody
    • DDRGK domain containing 1 antibody
    • DDRGK domain containing protein 1 antibody
    • DDRGK domain-containing protein 1 antibody
    • DDRGK_HUMAN antibody
    • Ddrgk1 antibody
    • dJ1187M17.3 antibody
    • MGC2592 antibody
    • OTTHUMP00000030088 antibody
    • RGD1309979 antibody
    • RP23-100C5.9 antibody
    • UFM1-binding and PCI domain-containing protein 1 antibody
    see all

Anti-DDRGK1 antibody 图像

  • Anti-DDRGK1 antibody (ab99121) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Predicted band size : 36 kDa

Anti-DDRGK1 antibody (ab99121)参考文献

ab99121 has not yet been referenced specifically in any publications.

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