概述

  • 产品名称Anti-DCUN1D3抗体
    参阅全部 DCUN1D3 一抗
  • 描述
    兔多克隆抗体to DCUN1D3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (HREEQVPPCG KPGGDILVNG TKKAEAATEA CQLPTSSGDA GRESKSNAEE) of Human DCUN1D3 (NP_775746).

  • 阳性对照
    • Fetal kidney lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab94454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).
  • 组织特异性Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma.
  • 序列相似性Contains 1 DCUN1 domain.
  • 结构域The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 44M2.4 antibody
    • DCN1 defective in cullin neddylation 1 domain containing 3 (S. cerevisiae) antibody
    • DCN1 defective in cullin neddylation 1 domain containing 3 antibody
    • DCN1 like protein 3 antibody
    • DCN1-like protein 3 antibody
    • DCNL3_HUMAN antibody
    • DCUN1 domain containing protein 3 antibody
    • DCUN1 domain-containing protein 3 antibody
    • dcun1d3 antibody
    • Defective in cullin neddylation protein 1 like protein 3 antibody
    • Defective in cullin neddylation protein 1-like protein 3 antibody
    • DKFZp686O0290 antibody
    • FLJ41725 antibody
    • MGC48972 antibody
    • Squamous cell carcinoma-related oncogene 3 antibody
    see all

Anti-DCUN1D3 antibody 图像

  • Anti-DCUN1D3 antibody (ab94454) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal kidney lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 34 kDa

Anti-DCUN1D3 antibody (ab94454)参考文献

ab94454 has not yet been referenced specifically in any publications.

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