概述

  • 产品名称Anti-DcR1抗体
    参阅全部 DcR1 一抗
  • 描述
    山羊多克隆抗体to DcR1
  • 特异性<0.2% cross-reactivity to TRAIL R2 peptide of the same region. Not likely to bind TRAIL R1 due to low sequence homology in this region. May bind TRAIL R4. May cross react to mouse TRAIL R3 as antibody binds to a similar size protein from mouse spleen on Westerns.
  • 经测试应用适用于: ELISA, Flow Cyt, ICC, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTC

    , corresponding to N terminal amino acids 33-64 of Human DcR1.

  • 阳性对照
    • Human embryonic kidney cell line-293 or human T-cell line Jurkatt.
  • 常规说明TRAIL R3 = "TNF Related Apoptosis Inducing Ligand Receptor 3"

性能

应用

Our Abpromise guarantee covers the use of ab1674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
Flow Cyt
ICC
WB
  • 应用说明ELISA: Use at a dilution > 1/150000.
    Flow Cyt: Use at an assay dependant dilution.
    ICC: 1/300.
    WB: 1/1000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
    • 细胞定位Cell Membrane and Cytoplasmic
    • 数据库链接
    • 别名
      • Antagonist decoy receptor for TRAIL/Apo 2L antibody
      • CD263 antibody
      • Cytotoxic TRAIL receptor 3 antibody
      • DCR1 antibody
      • DCR1 TNFR antibody
      • Decoy Receptor 1 antibody
      • Decoy TRAIL receptor without death domain antibody
      • LIT antibody
      • Lymphocyte inhibitor of TRAIL antibody
      • MGC149501 antibody
      • MGC149502 antibody
      • TNF related apoptosis inducing ligand receptor 3 antibody
      • TNF-re ated apoptosis inducing ligand receptor 3 antibody
      • TNFRSF10C antibody
      • TRAIL R3 antibody
      • TRAIL receptor 3 antibody
      • TRAILR3 antibody
      • TRID antibody
      • Tumor necrosis factor receptor superfamily member 10C antibody
      • Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain antibody
      see all

    Anti-DcR1 antibody 图像

    • ab1674 recognizes a 66kDa band of expected size in Lane 1 containing TRAIL-3R-Fc protein and showed minimal or no crossreactivity to TRAIL-2R-Fc protein in Lane 2.

    Anti-DcR1 antibody (ab1674)参考文献

    ab1674 has not yet been referenced specifically in any publications.

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