Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Belongs to the DCK/DGK family.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Kerr M et al. Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer. Clin Cancer Res20:5435-45 (2014).
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Frese KK et al. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov2:260-269 (2012).
Read more (PubMed: 22585996) »