概述

  • 产品名称Anti-DCK抗体[2243C2]
    参阅全部 DCK 一抗
  • 描述
    小鼠单克隆抗体[2243C2] to DCK
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment (N-terminal).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted |(approximately 95%) feta bovine serum. Filtered through a 0.22 micrometer membrane.
  • 克隆单克隆
  • 克隆编号2243C2
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab51517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
  • 序列相似性Belongs to the DCK/DGK family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • dCK antibody
    • DCK protein antibody
    • DCK_HUMAN antibody
    • Deoxycytidine kinase antibody
    • Deoxynucleoside kinase antibody
    • EC 2.7.1 antibody
    • EC 2.7.1.74 antibody
    • MGC117410 antibody
    • MGC138632 antibody
    • OTTHUMP00000219118 antibody
    • OTTHUMP00000219119 antibody
    see all

Anti-DCK antibody [2243C2] 图像

  • Anti-DCK antibody [2243C2] (ab51517) + Immunized recombinant protein

    Predicted band size : 31 kDa
    Observed band size : 31 kDa

Anti-DCK antibody [2243C2] (ab51517)参考文献

This product has been referenced in:
  • Neschadim A  et al. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Mol Ther 20:1002-13 (2012). WB ; Human . Read more (PubMed: 22273576) »
  • Likar Y  et al. A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. J Nucl Med 51:1395-403 (2010). WB ; Human . Read more (PubMed: 20810757) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"