概述

  • 产品名称Anti-DCC抗体
    参阅全部 DCC 一抗
  • 描述
    山羊多克隆抗体to DCC
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    C-KQLNAITGSAF

    , corresponding to amino acids 1437-1447 of Human DCC (NP_005206.2).

  • 阳性对照
    • Human adrenal and liver tissues

性能

应用

Our Abpromise guarantee covers the use of ab118597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 2.5 - 5 µg/ml.

靶标

  • 功能Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
  • 组织特异性Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
  • 疾病相关Defects in DCC are the cause of congenital mirror movements (MIMOC) [MIM:157600]. Mirror movements are contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.
  • 序列相似性Belongs to the immunoglobulin superfamily. DCC family.
    Contains 6 fibronectin type-III domains.
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Colorectal cancer related chromosome sequence 18 antibody
    • Colorectal cancer suppressor antibody
    • CRC 18 antibody
    • CRC18 antibody
    • CRCR 1 antibody
    • CRCR1 antibody
    • DCC antibody
    • DCC_HUMAN antibody
    • Deleted in colorectal cancer protein antibody
    • Deleted in colorectal carcinoma antibody
    • Immunoglobulin superfamily DCC subclass member 1 antibody
    • Netrin receptor DCC antibody
    • Tumor suppressor protein DCC antibody
    see all

Anti-DCC antibody 图像

  • ab118597, at 5 µg/ml, staining DCC in formalin fixed, paraffin embedded Human adrenal tissue by Immunohistochemistry.
  • ab118597, at 5 µg/ml, staining DCC in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry.

Anti-DCC antibody (ab118597)参考文献

ab118597 has not yet been referenced specifically in any publications.

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