概述

  • 产品名称Anti-DBF4抗体
    参阅全部 DBF4 一抗
  • 描述
    山羊多克隆抗体to DBF4
  • 特异性ab116613 is expected to recognize both reported isoforms (NP_038754.1; NP_001177646.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    DKKRTEYLPAHEDRT

    with a Cysteine residue linker, corresponding to internal sequence amino acids 585-599 of Mouse DBF4 (NP_038754.1; NP_001177646.1).

  • 阳性对照
    • Mouse and Rat Testis lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab116613 is purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 74 kDa.

靶标

  • 功能Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
  • 组织特异性Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
  • 序列相似性Contains 2 BRCT domains.
    Contains 1 DBF4-type zinc finger.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activator of S phase kinase antibody
    • ASK antibody
    • CHIF antibody
    • Chiffon homolog A antibody
    • DBF4 antibody
    • DBF4 homolog (S. cerevisiae) antibody
    • DBF4 homolog antibody
    • DBF4 type zinc finger containing protein 1 antibody
    • DBF4 zinc finger A antibody
    • DBF4 zinc finger antibody
    • DBF4, S. cerevisiae, homolog of antibody
    • DBF4-type zinc finger-containing protein 1 antibody
    • DBF4A antibody
    • DBF4A_HUMAN antibody
    • Dumbbell former 4, S. cerevisiae, homolog of antibody
    • OTTHUMP00000161661 antibody
    • Protein DBF4 homolog A antibody
    • ZDBF1 antibody
    • Zinc finger, DBF-type containing 1 antibody
    see all

Anti-DBF4 antibody 图像

  • Anti-DBF4 antibody (ab116613) at 1 µg/ml + Mouse testis lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 74 kDa

Anti-DBF4 antibody (ab116613)参考文献

ab116613 has not yet been referenced specifically in any publications.

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