概述

  • 产品名称
  • 描述
    兔多克隆抗体to DAZ2
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 1 - 207 of Human DAZ2 (NP_065096).

  • 阳性对照
    • WB: 293T, A431, HeLa, MOLT4 and Raji cell lysate IF: HeLa cells

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab97772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 63 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  • 组织特异性
    Testis specific.
  • 疾病相关
    Defects in DAZ2 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.
  • 序列相似性
    Belongs to the RRM DAZ family.
    Contains 15 DAZ-like domains.
    Contains 1 RRM (RNA recognition motif) domain.
  • 结构域
    The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • 细胞定位
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DAZ2 antibody
    • DAZ2_HUMAN antibody
    • DAZ3 antibody
    • Deleted in azoospermia 2 antibody
    • Deleted in azoospermia protein 2 antibody
    • Deleted in azoospermia protein 3 antibody
    • MGC126442 antibody
    • pDP1678 antibody
    see all

Anti-DAZ2 antibody 图像

  • Anti-DAZ2 antibody (ab97772) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 63 kDa
  • ab97772, at a 1/200 dilution, staining DAZ2 in paraformaldehyde-fixed HeLa cells by Immunofluorescence analysis. Right image is merged with a DNA probe.

Anti-DAZ2 antibody (ab97772)参考文献

ab97772 has not yet been referenced specifically in any publications.

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