概述

  • 产品名称
  • 描述
    兔多克隆抗体to DAP12
  • 特异性
    ab25098 recognises recombinant and natural DAP12.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    E. coli expressed recombinant fragment:

    QSDNYPGCECSSV

    , corresponding to amino acids 28/40 of Rat DAP12

  • 阳性对照
    • Day 8 tubular interstitial nephritis model

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 13 kDa.

靶标

  • 功能
    Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation.
  • 组织特异性
    Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
  • 疾病相关
    Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
  • 序列相似性
    Belongs to the TYROBP family.
  • 翻译后修饰
    Tyrosine phosphorylated.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DAP 12 antibody
    • DAP12 antibody
    • DNAX activation protein 12 antibody
    • DNAX-activation protein 12 antibody
    • KAR-associated protein antibody
    • KARAP antibody
    • Killer activating receptor associated protein antibody
    • Killer-activating receptor-associated protein antibody
    • PLOSL antibody
    • TYOBP_HUMAN antibody
    • TYRO protein tyrosine kinase binding protein antibody
    • TYRO protein tyrosine kinase-binding protein antibody
    • TYROBP antibody
    see all

图片

  • All lanes : Anti-DAP12 antibody (ab25098) at 1/1000 dilution

    Lane 1 : Day 3 tubular interstitial nephritis model
    Lane 2 : Day 8 tubular interstitial nephritis model
    Lane 3 : Day 10 tubular interstitial nephritis model


    Predicted band size : 13 kDa
    Observed band size : 13 kDa

实验方案

文献

ab25098 has not yet been referenced specifically in any publications.

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