Anti-DAP12抗体(ab110117)

概述

  • 产品名称
  • 描述
    山羊多克隆抗体to DAP12
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Sheep, Dog
  • 免疫原

    Synthetic peptide:

    KQRITETESPYQE

    , corresponding to amino acids 81-93 of Human DAP12

  • 阳性对照
    • Human Spleen and Human Uterus tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation.
  • 组织特异性
    Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
  • 疾病相关
    Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
  • 序列相似性
    Belongs to the TYROBP family.
  • 翻译后修饰
    Tyrosine phosphorylated.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DAP 12 antibody
    • DAP12 antibody
    • DNAX activation protein 12 antibody
    • DNAX-activation protein 12 antibody
    • KAR-associated protein antibody
    • KARAP antibody
    • Killer activating receptor associated protein antibody
    • Killer-activating receptor-associated protein antibody
    • PLOSL antibody
    • TYOBP_HUMAN antibody
    • TYRO protein tyrosine kinase binding protein antibody
    • TYRO protein tyrosine kinase-binding protein antibody
    • TYROBP antibody
    see all

Anti-DAP12 antibody 图像

  • Human Spleen (formalin-fixed, paraffin-embedded) stained with 3 µg/ml ab110117 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Uterus (formalin-fixed, paraffin-embedded) stained with 3 µg/ml ab110117 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-DAP12 antibody (ab110117)参考文献

ab110117 has not yet been referenced specifically in any publications.

Product Wall

Application
Immunohistochemistry (Frozen sections)
Blocking step
Serum as blocking agent for 12 hour(s) and 0 minute(s) · Concentration: 10%
Sample
Human Tissue sections (Human brain section)
Specification
Human brain section
Permeabilization
Yes - 0.1% TritonX in 0.1% PBS
Fixative
Formaldehyde
Username

Dr. Ruma Raha-Chowdhury

Verified customer

提交于 Aug 06 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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