概述

  • 产品名称Anti-DACH2抗体
    参阅全部 DACH2 一抗
  • 描述
    兔多克隆抗体to DACH2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide derived from a region between amino acids 525-574 of human DACH2. (Note:the exact amino acid sequence is proprietary)

  • 阳性对照
    • Jurkat cell lysate, human liver.

性能

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应用

Our Abpromise guarantee covers the use of ab30909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 65 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.
  • 序列相似性Belongs to the DACH/dachshund family.
  • 结构域The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DACH 2 antibody
    • Dach2 antibody
    • DACH2_HUMAN antibody
    • Dachshund 2 antibody
    • Dachshund homolog 2 (Drosophila) antibody
    • Dachshund homolog 2 antibody
    • Dachshund2 antibody
    • FLJ31391 antibody
    • HGNC:16814 antibody
    • MGC138545 antibody
    see all

Anti-DACH2 antibody 图像

Anti-DACH2 antibody (ab30909)参考文献

ab30909 has not yet been referenced specifically in any publications.

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