概述

  • 产品名称
  • 描述
    山羊多克隆抗体to DACH1
  • 特异性
    ab106838 is expected to recognise all three reported isoforms(NP_542937.1; NP_542938.1; NP_004383.2).
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to internal sequence amino acids 179-191 (

    SPVENTPQNNECK

    ) of Human DACH1 (NP_542937.1; NP_542938.1; NP_004383.2)

  • 阳性对照
    • Human kidney tissue lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 79 kDa.

靶标

  • 功能
    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
  • 组织特异性
    Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
  • 序列相似性
    Belongs to the DACH/dachshund family.
  • 结构域
    The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DACH antibody
    • Dach1 antibody
    • DACH1_HUMAN antibody
    • dachshund homolog 1 (Drosophila) antibody
    • Dachshund homolog 1 antibody
    • Dachsund homolog 1 antibody
    • FLJ10138 antibody
    • OTTHUMP00000018494 antibody
    see all

Anti-DACH1 antibody 图像

  • Anti-DACH1 antibody (ab106838) at 0.1 µg/ml + Human Kidney lysate in RIPA buffer at 35 µg

    Predicted band size : 79 kDa
    Additional bands at : 52 kDa (possible isoform),57 kDa (possible isoform),73 kDa (possible isoform).

实验方案

Anti-DACH1 antibody (ab106838)参考文献

ab106838 has not yet been referenced specifically in any publications.

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