概述

  • 产品名称D-AP5
  • 描述
    NMDA glutamate site antagonist
  • 别名
    • APV
    • D-APV
  • 生物学描述

    Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.

    Also available in simple stock solutions (ab144482) - add 1 ml of water to get an exact, ready-to-use concentration.

  • 纯度> 99%

性能

    D-AP5 图像

    • Averaged Ca2+ transients (500 Hz line scans) evoked by 40 ms voltage step in a dendrite (left) and spine (right) in control (black), D-AP5 (red, 10 µM), after a 10 min washout of D-AP5 (green), and in 5 µM NMDA (blue). Mibefradil (20 µM), nimodipine (20 µM) and TTX (0.5 µM) were present throughout.
    • Representative voltage-clamp recording (Vh= −60 mV, ECl−=+8 mV) of a Purkinje cells response to simulated ischemia and sequential block of glutamate receptors and GABAA receptors.

    D-AP5 (ab120003)参考文献

    This product has been referenced in:
    • Kew JN & Kemp JA Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179:4-29 (2005). Read more (PubMed: 15731895) »
    • Davies J & Watkins JC Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res 235:378-86 (1982). Read more (PubMed: 6145492) »
    • Evans RH  et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol 75:65-75 (1982). Read more (PubMed: 7042024) »

    See all 129 Publications for this product

    Product Wall

    We have not previously experienced any issues with D-AP5 (ab120003) and we are confident that it is soluble to 100 mM in water. I noticed that the *competitor name* product page that you linked to was for DL-AP5 rather than D-AP5. DL-AP5 has a lower so...

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    Thank you foryour inquiry.

    It is regrettable the results with ab120003have not been successful.

    I double checked with the lab and the #competitor# Website and I can confirm that D-AP5 (CAS number 79055-68-8) is soluble in water to 1...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"