Anti-Cytokeratin抗体[CK 210 and CK 211 (AE1+AE3] (ab115963)

概述

  • 产品名称
    Anti-Cytokeratin抗体[CK 210 and CK 211 (AE1+AE3]
    参阅全部 Cytokeratin 一抗
  • 描述
    小鼠单克隆抗体[CK 210 and CK 211 (AE1+AE3] to Cytokeratin
  • 经测试应用
    适用于: IHC-P, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Chicken, Cow, Human, Pig, Monkey
  • 免疫原

    Full length native protein (purified) corresponding to Human Cytokeratin.

  • 阳性对照
    • Human skin, lung carcinoma tissues.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    pH: 7.40
    Preservative: 0.05% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • 纯度
    Ascites
  • 克隆
    单克隆
  • 克隆编号
    CK 210 and CK 211 (AE1+AE3
  • 同种型
    IgG1
  • 轻链类型
    kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. An antigen retriever like trypsin is required.
IHC-Fr 1/50 - 1/100.
ICC Use at an assay dependent concentration.

靶标

  • 功能
    May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).
  • 组织特异性
    The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
  • 疾病相关
    Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
    Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
    Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
    Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
    Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
  • 序列相似性
    Belongs to the intermediate filament family.
  • 翻译后修饰
    Undergoes deimination of some arginine residues (citrullination).
  • 细胞定位
    Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 67 kDa cytokeratin antibody
    • CK-1 antibody
    • CK1 antibody
    • Cytokeratin 1 antibody
    • Cytokeratin 19 antibody
    • Cytokeratin 8 antibody
    • Cytokeratin-1 antibody
    • EHK antibody
    • EHK1 antibody
    • epidermolytic hyperkeratosis 1 antibody
    • EPPK antibody
    • Hair alpha protein antibody
    • K1 antibody
    • K2C1_HUMAN antibody
    • KB1 antibody
    • Keratin 1 antibody
    • keratin 1, type II antibody
    • Keratin 19 antibody
    • Keratin 8 antibody
    • Keratin antibody
    • keratin, type II cytoskeletal 1 antibody
    • Keratin-1 antibody
    • Krt1 antibody
    • KRT19 antibody
    • KRT1A antibody
    • KRT8 antibody
    • KRTA antibody
    • NEPPK antibody
    • type II cytoskeletal 1 antibody
    • Type-II keratin Kb1 antibody
    see all

Anti-Cytokeratin antibody [CK 210 and CK 211 (AE1+AE3] (ab115963)参考文献

ab115963 has not yet been referenced specifically in any publications.

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