Anti-Cytokeratin AE3抗体[CK 211 (AE3)] (ab115983)

概述

  • 产品名称Anti-Cytokeratin AE3抗体[CK 211 (AE3)]
  • 描述
    小鼠单克隆抗体[CK 211 (AE3)] to Cytokeratin AE3
  • 特异性ab115983 reacts Cytokeratins 1, 2, 3, 4, 5 6 and 8.
  • 经测试应用适用于: IHC-P, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Chicken, Cow, Human, Pig, Monkey
  • 免疫原

    Human epidermal keratin

  • 阳性对照
    • Human skin tissue and lung carcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.40
    Preservative: 0.05% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号CK 211 (AE3)
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab115983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. An antigen retriever like trypsin is required.
IHC-Fr 1/50 - 1/100.
ICC Use at an assay dependent concentration.

靶标

  • 组织特异性Cornea specific.
  • 疾病相关Defects in KRT3 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated as MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
  • 序列相似性Belongs to the intermediate filament family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 65 kDa cytokeratin antibody
    • CK-3 antibody
    • CK3 antibody
    • Cytokeratin-3 antibody
    • FLJ95909 antibody
    • K2C3_HUMAN antibody
    • K3 antibody
    • Keratin antibody
    • Keratin-3 antibody
    • KRT3 antibody
    • type II cytoskeletal 3 antibody
    • Type-II keratin Kb3 antibody
    see all

Anti-Cytokeratin AE3 antibody [CK 211 (AE3)] (ab115983)参考文献

ab115983 has not yet been referenced specifically in any publications.

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