Anti-Cytokeratin 5抗体(ab83168)

概述

  • 产品名称Anti-Cytokeratin 5抗体
    参阅全部 Cytokeratin 5 一抗
  • 描述
    兔多克隆抗体to Cytokeratin 5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Mouse Cytokeratin 5.

    (Peptide available as ab93081.)

  • 阳性对照
    • This antibody gave a positive signal in A431 whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab83168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 64 kDa (predicted molecular weight: 62 kDa).
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 疾病相关Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
      Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema (EBSMCE) [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
      Defects in KRT5 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
      Defects in KRT5 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe.
      Defects in KRT5 are the cause of epidermolysis bullosa simplex with mottled pigmentation (MP-EBS) [MIM:131960]. MP-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
      Defects in KRT5 are the cause of Dowling-Degos disease (DDD) [MIM:179850]; also known as Dowling-Degos-Kitamura disease or reticulate acropigmentation of Kitamura. DDD is an autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.
    • 序列相似性Belongs to the intermediate filament family.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 58 kDa cytokeratin antibody
      • CK-5 antibody
      • CK5 antibody
      • Cytokeratin-5 antibody
      • Cytokeratin5 antibody
      • DDD antibody
      • DDD1 antibody
      • EBS2 antibody
      • epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types antibody
      • K2C5_HUMAN antibody
      • K5 antibody
      • keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) antibody
      • Keratin 5 antibody
      • Keratin antibody
      • keratin complex 2, basic, gene 5 antibody
      • keratin, type II cytoskeletal 5 antibody
      • Keratin-5 antibody
      • Keratin5 antibody
      • KRT 5 antibody
      • Krt5 antibody
      • KRT5A antibody
      • type II cytoskeletal 5 antibody
      • Type-II keratin Kb5 antibody
      see all

    Anti-Cytokeratin 5 antibody 图像

    • Anti-Cytokeratin 5 antibody (ab83168) at 1 µg/ml + A431 (Human epithelial carcinoma cell line) Whole Cell Lysate at 10 µg

      Secondary
      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
      Developed using the ECL technique

      Performed under reducing conditions.

      Predicted band size : 62 kDa
      Observed band size : 64 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 49 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 30 seconds

    Anti-Cytokeratin 5 antibody (ab83168)参考文献

    ab83168 has not yet been referenced specifically in any publications.

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