Anti-Cytokeratin 5抗体(ab74526)

概述

  • 产品名称Anti-Cytokeratin 5抗体
    参阅全部 Cytokeratin 5 一抗
  • 描述
    兔多克隆抗体to Cytokeratin 5
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to C-terminal of human Cytokeratin 5.

  • 阳性对照
    • Human mesothelioma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab74526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 for 30 min at RT.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 疾病相关Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
      Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema (EBSMCE) [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
      Defects in KRT5 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
      Defects in KRT5 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe.
      Defects in KRT5 are the cause of epidermolysis bullosa simplex with mottled pigmentation (MP-EBS) [MIM:131960]. MP-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
      Defects in KRT5 are the cause of Dowling-Degos disease (DDD) [MIM:179850]; also known as Dowling-Degos-Kitamura disease or reticulate acropigmentation of Kitamura. DDD is an autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.
    • 序列相似性Belongs to the intermediate filament family.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 58 kDa cytokeratin antibody
      • CK-5 antibody
      • CK5 antibody
      • Cytokeratin-5 antibody
      • Cytokeratin5 antibody
      • DDD antibody
      • DDD1 antibody
      • EBS2 antibody
      • epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types antibody
      • K2C5_HUMAN antibody
      • K5 antibody
      • keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) antibody
      • Keratin 5 antibody
      • Keratin antibody
      • keratin complex 2, basic, gene 5 antibody
      • keratin, type II cytoskeletal 5 antibody
      • Keratin-5 antibody
      • Keratin5 antibody
      • KRT 5 antibody
      • Krt5 antibody
      • KRT5A antibody
      • type II cytoskeletal 5 antibody
      • Type-II keratin Kb5 antibody
      see all

    Anti-Cytokeratin 5 antibody 图像

    • ab74526 at 1/100 dilution staining Cytokeratin 5 in Human mesothelioma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

    Anti-Cytokeratin 5 antibody (ab74526)参考文献

    ab74526 has not yet been referenced specifically in any publications.

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