Anti-Cytokeratin 5 + 14抗体[XM26 & LL002], prediluted (ab59693)

概述

  • 产品名称Anti-Cytokeratin 5 + 14抗体[XM26 & LL002], prediluted
    参阅全部 Cytokeratin 5 + 14 一抗
  • 描述
    小鼠单克隆抗体[XM26 & LL002] to Cytokeratin 5 + 14, prediluted
  • 特异性This antibody cocktail reacts with cytokeratin 5 intermediate filament protein as well as to 50 kD cytokeratin protein designated cytokeratin 14
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    XM26: Prokaryotic recombinant protein corresponding to 103 amino acid portion of C terminal region of the human Cytokeratin 5 molecule. LL002: Synthetic peptide of the extreme C terminal of human Cytokeratin 14.

  • 阳性对照
    • Skin
  • 常规说明The isotypes for both clones are as follows: XM26 - IgG1 LL002 - IgG3


    Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

性能

  • 形式Prediluted
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: Inert stabilizer
  • Concentration information loading...
  • Primary antibody说明Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
  • 克隆单克隆
  • 克隆编号XM26 & LL002
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use at an assay dependent concentration. Incubation for 30 minutes at room temperature is recommended.

靶标

  • 相关性Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
  • 细胞定位Cytoplasmic; Basal layer
  • 数据库链接
  • 别名
    • CK 14 antibody
    • CK 5 antibody
    • DDD antibody
    • k14 antibody
    • k5 antibody
    • Keratin 14 antibody
    • Keratin 5 antibody
    • Keratin type I cytoskeletal 14 antibody
    • Keratin type II cytoskeletal 5 antibody
    • krt14 antibody
    • krt5 antibody
    see all

Anti-Cytokeratin 5 + 14 antibody [XM26 & LL002], prediluted 图像

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human tonsil tissue sections, labelling Cytokeratin 5/14 with ab59693.

Anti-Cytokeratin 5 + 14 antibody [XM26 & LL002], prediluted (ab59693)参考文献

ab59693 has not yet been referenced specifically in any publications.

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