Anti-Cytokeratin 20抗体[BV12], prediluted (ab73096)


  • 产品名称Anti-Cytokeratin 20抗体[BV12], prediluted
    参阅全部 Cytokeratin 20 一抗
  • 描述
    兔单克隆抗体[BV12] to Cytokeratin 20, prediluted
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide from the C-terminus of human Cytokeratin 20 protein.

  • 阳性对照
    • Colon carcinoma tissue.



Our Abpromise guarantee covers the use of ab73096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: Use neat for 30-60 minutes at room temperature.
    Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1 mM EDTA buffer, pH 8.0 prior to immunostaining.
    IHC-Fr (acetone-fixed): Use neat for 30-60 minutes at room temperature.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
    • 组织特异性Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
    • 序列相似性Belongs to the intermediate filament family.
    • 发展阶段First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.
    • 翻译后修饰Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury.
      Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD20 antibody
      • CK 20 antibody
      • CK-20 antibody
      • CK20 antibody
      • Cytokeratin-20 antibody
      • Cytokeratin20 antibody
      • K1C20_HUMAN antibody
      • K20 antibody
      • KA20 antibody
      • Keratin 20 antibody
      • keratin 20, type I antibody
      • keratin 21, rat, homolog of antibody
      • Keratin antibody
      • Keratin type I cytoskeletal 20 antibody
      • Keratin-20 antibody
      • Keratin20 antibody
      • KRT 20 antibody
      • KRT 21 antibody
      • KRT20 antibody
      • KRT21 antibody
      • MGC35423 antibody
      • OTTHUMP00000164518 antibody
      • Protein IT antibody
      • type I cytoskeletal 20 antibody
      see all

    Anti-Cytokeratin 20 antibody [BV12], prediluted 图像

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue, staining Cytokeratin 20 with ab73096.

    Anti-Cytokeratin 20 antibody [BV12], prediluted (ab73096)参考文献

    ab73096 has not yet been referenced specifically in any publications.

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