RabMAb

Anti-Cytokeratin 18抗体[SP69], prediluted (ab101542)

概述

  • 产品名称Anti-Cytokeratin 18抗体[SP69], prediluted
    参阅全部 Cytokeratin 18 一抗
  • 描述
    兔单克隆抗体[SP69] to Cytokeratin 18, prediluted
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to the C terminus of Human Cytokeratin 18.

  • 阳性对照
    • Human breast carcinomaand Human prostate carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab101542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1. (Prediluted). Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.
WB Use at an assay dependent concentration. Predicted molecular weight: 48 kDa.

靶标

  • 功能Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
  • 组织特异性Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
  • 疾病相关Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600].
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
    Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
    O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.
  • 细胞定位Cytoplasm > perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cell proliferation inducing gene 46 protein antibody
    • Cell proliferation inducing protein 46 antibody
    • Cell proliferation-inducing gene 46 protein antibody
    • CK 18 antibody
    • CK-18 antibody
    • CK18 antibody
    • CYK 18 antibody
    • CYK18 antibody
    • Cytokeratin 18 antibody
    • Cytokeratin endo B antibody
    • Cytokeratin-18 antibody
    • K 18 antibody
    • K18 antibody
    • K1C18_HUMAN antibody
    • KA18 antibody
    • Keratin 18 antibody
    • Keratin 18, type I antibody
    • Keratin D antibody
    • keratin, type I cytoskeletal 18 antibody
    • Keratin-18 antibody
    • Krt18 antibody
    see all

Anti-Cytokeratin 18 antibody [SP69], prediluted 图像

  • ab101542, prediluted, staining Cytokeratin 18 in formalin fixed, paraffin embedded Human breast carcinoma by Immunohistochemistry.
  • Anti-Cytokeratin 18 antibody [SP69] (ab93741) at 1/100 dilution + MCF-7 cell lysate

    Predicted band size : 48 kDa

Anti-Cytokeratin 18 antibody [SP69], prediluted (ab101542)参考文献

ab101542 has not yet been referenced specifically in any publications.

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