Anti-Cytokeratin 17抗体- Cytoskeleton Marker (ab52892)


  • 产品名称Anti-Cytokeratin 17抗体- Cytoskeleton Marker
    参阅全部 Cytokeratin 17 一抗
  • 描述
    兔多克隆抗体to Cytokeratin 17 - Cytoskeleton Marker
  • 经测试应用适用于: WB, Flow Cyt, IHC-P, ICC/IFmore details
    不适用于: IP
  • 种属反应性
    与反应: Rat, Human
    不与反应: Mouse
  • 免疫原

    Synthetic peptide corresponding to residues on the N-terminus of human Cytokeratin 17.

  • 阳性对照
    • HeLa cell lysate, human cervical carcinoma tissue or HeLa cells.



Our Abpromise guarantee covers the use of ab52892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Detects a band of approximately 50 kDa (predicted molecular weight: 48 kDa).
Flow Cyt 1/10. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IHC-P Use at an assay dependent concentration.
ICC/IF 1/50 - 1/100.
  • 应用说明Is unsuitable for IP.
  • 靶标

    • 功能May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
    • 组织特异性Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
    • 疾病相关Defects in KRT17 are a cause of pachyonychia congenita type 2 (PC2) [MIM:167210]; also known as pachyonychia congenita Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
      Defects in KRT17 are a cause of steatocystoma multiplex (SM) [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
      Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
    • 序列相似性Belongs to the intermediate filament family.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 39.1 antibody
      • CK 17 antibody
      • CK-17 antibody
      • Cytokeratin-17 antibody
      • K17 antibody
      • K1C17_HUMAN antibody
      • Keratin 17 antibody
      • keratin 17 epitope S1 antibody
      • keratin 17 epitope S2 antibody
      • keratin 17 epitope S4 antibody
      • Keratin antibody
      • Keratin type I cytoskeletal 17 antibody
      • keratin, type i cytoskeletal 17 [version 1] antibody
      • Keratin-17 antibody
      • KRT17 antibody
      • PC antibody
      • PC2 antibody
      • PCHC1 antibody
      • type I cytoskeletal 17 antibody
      see all

    Anti-Cytokeratin 17 antibody - Cytoskeleton Marker 图像

    • Anti-Cytokeratin 17 antibody - Cytoskeleton Marker (ab52892) at 1/2000 dilution + HeLa cell lysate at 10 µg

      Goat anti-Rabbit HRP labeled at 1/2000 dilution

      Predicted band size : 48 kDa
      Observed band size : 50 kDa (why is the actual band size different from the predicted?)
    • Ab52892 (1:100) staining human Cytokeratin 17 in human cervical carcinoma tissue by immunohistochemistry using paraffin embedded tissue.
    • Immunofluorescent staining of HeLa cells using ab52892 (1:50).

    Anti-Cytokeratin 17 antibody - Cytoskeleton Marker (ab52892)参考文献

    ab52892 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab52892.
    Please use the links above to contact us or submit feedback about this product.